Estudio sobre los niveles de melatonina en pacientes con epilepsia

El objetivo principal del estudio fue la creación de un modelo matemático capaz de describir la secreción circadiano de la melatonina y hacer una comparación de la secreción de melatonina en niños con y sin epilepsia. El análisis de correlación realizados para grupos de niños con y sin epilepsia ha demostrado que los pacientes con epilepsia se caracterizan por una mayor descoordinación de la liberación de la melatonina.

Studio in inglese

Melatonin in Epilepsy: A New Mathematical Model of Diurnal Secretion.

Int J Endocrinol. 2016;2016:3861461
Authors: Paprocka J, Kijonka M, Pęcka M, Sokół M

Abstract
Purpose. The main objective of the study was to create a mathematical model that describes the melatonin circadian secretion and, then the functionality of the model was tested by a comparison of the melatonin secretions in children with and without epilepsy. Material and Methods. The patients were divided into the epilepsy group (EG, n = 52) and the comparison group (CG, n = 30). The melatonin level was assessed by a radioimmunoassay method. The diurnal melatonin secretion was described using a nonlinear least squares method. Spearman's rank correlation coefficient was chosen to estimate the dependence of the acquired data. The model reproduces blood concentration profiles and its parameters were statistically analyzed using the Mann-Whitney-Wilcoxon test and logistic regression. Results. The correlation analysis performed for the EG and CG groups showed moderate correlations between age and the melatonin secretion model parameters. Patients with epilepsy are characterized by an increased phase shift of melatonin release.

PMID: 27478439 [PubMed]
http://www.ncbi.nlm.nih.gov/pubmed/27478439?dopt=Abstract

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