Los efectos anti-inflamatorios de la melatonina en la esclerosis múltiple



La esclerosis múltiple es una enfermedad auto-inmune caracterizada por una respuesta inmunitaria directa con la desregularización del sistema nervioso central. Estudios recientes sugieren que tomar melatonina es útil en pacientes que sufren de esclerosis múltiple gracias a sus efectos anti-inflamatorios.

Anti-inflammatory effects of melatonin in multiple sclerosis.

Bioessays. 2016 Aug 26;
Authors: Farez MF, Calandri IL, Correale J, Quintana FJ

Abstract
Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4(+) T cells secreting IFN-γ (TH 1) or IL-17 (TH 17); and FoxP3(+) regulatory T cells and IL-10(+) type 1 regulatory T cells (Tr1 cells) is thought to play an important role in disease activity. Recent evidence suggests that melatonin ameliorates multiple sclerosis by controlling the balance between effector and regulatory cells, suggesting that melatonin-triggered signaling pathways are potential targets for therapeutic intervention. Here, we review the available data on the effects of melatonin on immune processes relevant for MS and discuss its therapeutic potential.

PMID: 27561251 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27561251?dopt=Abstract


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