Estudio sobre la correlación entre los niveles bajos de melatonina en la saliva y los síntomas depresivos en pacientes psiquiátricos
El objetivo de la investigación fue investigar la correlación entre los niveles bajos de melatonina en la saliva y la severidad de los síntomas depresivos en pacientes psiquiátricos jóvenes adultos. Los pacientes con niveles más bajos de melatonina al costarse fueron más propensos a un alto MADRS (Escala psiquiátrica utilizada para la evaluación de la depresión) en comparación a aquellos con niveles más altos de melatonina.
Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
PLoS One. 2016;11(4):e0152814
Authors: Sundberg I, Ramklint M, Stridsberg M, Papadopoulos FC, Ekselius L, Cunningham JL
Abstract
Reduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin (odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin levels may have prognostic implications.
PMID: 27042858 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27042858?dopt=Abstract
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