La propiedad antioxidante de la melatonina contra la isquemia cerebral

En este artículo científico se recogieron y se analizaron numerosos estudios que documentan la capacidad de la melatonina para limitar el daño molecular y el daño a los tejidos de los órganos en caso de daño neuronal a partir de la lesión por isquemia-reperfusión (accidente cerebrovascular).

The antioxidative property of melatonin against brain ischemia.

Expert Rev Neurother. 2016 Apr 24;

Authors: Paterniti I, Cordaro M, Esposito E, Cuzzocrea S

Abstract
This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction. Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N(1)-acetyl-N(2)-formyl-5- methoxykynuramine (AFMK) and N(1)-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin. However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified.

PMID: 27108742 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27108742?dopt=Abstract

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