La importancia de la melatonina, a través de la interacción y el efecto sobre las mitocondrias, en trastornos del humor y la esquizofrenia



Teniendo en cuenta que la melatonina tiene un efecto regulador sobre el ritmo circadiano y la calidad del sueño, que tiene una estrecha relación con los trastornos del humor y la esquizofrenia. En esta recolección de estudios han tratado de resumir los efectos de la melatonina en la actividad mitocondrial  en pacientes con esquizofrenia y trastornos de humor.

The importance of melatonin and mitochondria interaction in mood disorders and schizophrenia: A current assessment.

Curr Med Chem. 2016 Apr 27;

Authors: Uğuz AC, Demirci K, Palma JE

Abstract
Mitochondria play have a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with between schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin on mitochondrial activity in schizophrenia and mood disorders.

PMID: 27121187 [PubMed - as supplied by publisher]



Si te ha resultado interesante envíalo a un amigo o compártelo en tus redes sociales

|



Key Melatonin
www.melatonina.es